Lymph nodes are an important part of the body’s immune system. They are located throughout the body and help to attack germs and fight infection. A swollen lymph node is a physical sign of a health problem. It could be an infection or cold, injury, or in some cases, cancer. A cancer diagnosis is only confirmed through a biopsy and often leaves people wondering: is cancer of the lymph nodes terminal?

First, to perform a lymph node biopsy, doctors remove a fluid sample from one of the infected lymph nodes and look at the tissue up close under a microscope. Second, if cancer is detected, more tests are necessary to determine how far it has spread and where the tumors have originated from. At this point, it can then be determined which stage of cancer is present and whether it is terminal.

Cancerous tumors can develop anywhere in the body and eventually travel to the lymph nodes and other areas of the lymphatic system. When cancer cells escape tumors they may die off before they can begin growth somewhere else, but if they settle, grow, and continue to spread, this is referred to as cancer metastasis.

What Happens When Cancer Spreads To The Lymph Nodes? 

If cancer has metastasized, it could indicate the cancer is in a later stage and require more aggressive treatment. However, if cancerous cells in the lymph nodes are found near the original site of the primary tumor, it could mean the metastatic lymph node cancer is in an early stage and can be treated before the lymph node cancer begins to spread around the body and to another nearby lymph node and develop into a secondary cancer.1

What Is Cancer of the Lymph Nodes?

When cancer originates in the lymph nodes or other areas of the lymphatic system, it’s referred to as lymphoma.2 The most common types are Hodgkin lymphoma and Non-Hodgkin lymphoma. In rare instances, there’s also a chance for the development of lymphoma on the skin. If you’re wondering, “Is lymphoma hereditary,” we cover this question in our latest blog article.

People with Hodgkin lymphoma usually experience enlarged lymph nodes with a small number of Reed-Sternberg cells present surrounded by normal immune cells. With classic Hodgkin lymphoma, which accounts for 9 out of 10 cases of this cancer type, four subtypes may develop.3 These are:

  • Nodular sclerosis Hodgkin lymphoma is the most common and tends to start in the lymph nodes in the neck or chest. Though it is more prevalent in teens and young adults, it can develop at any age.
  • Mixed cellularity Hodgkin lymphoma is the second most common subtype and occurs mainly in the lymph nodes found in the upper half of the body. It’s mostly detected in people with HIV infection and affects mostly children and the elderly.
  • Lymphocyte-rich Hodgkin lymphoma is a rarer subtype and usually occurs in the upper half of the body in a few lymph nodes.
  • Lymphocyte-depleted Hodgkin lymphoma is the rarest subtype of this type of cancer and occurs mainly in older people with HIV infection. It’s mostly found in lymph nodes in the stomach, spleen, liver, and/or bone marrow.

Alternatively, non-Hodgkin lymphoma is a cancer that starts in the lymphocytes, or white blood cells in the immune system, and most often affects adults. It typically starts in lymph nodes or other lymph tissue and is categorized based on whether the B cells or T cells are affected.

Both B cells and T cells are responsible for protecting the body against germs, bacteria, and other damage to the immune system. Lymphoma cells can develop through either, though B-cell lymphoma is most common.4

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How to Detect Early Signs of Cancerous Lymph Nodes

When cancer cells have spread to the lymph nodes, some symptoms will appear. Identifying the signs cancer has spread to the lymph nodes not only aids in timely intervention but also helps in understanding the stage and potential prognosis of the cancer. These may include:

  • Swollen Lymph Nodes: One of the most common signs is the swelling of lymph nodes. This can occur in areas like the neck, armpit, or groin. These swellings are typically painless and may be indicative of cancer cells accumulating in the node.
  • Local Symptoms: Depending on the location of the affected lymph nodes, symptoms can vary. For instance, if lymph nodes near the lungs are involved, there might be coughing or shortness of breath.
  • Systemic Symptoms: As cancer progresses, systemic symptoms like unexplained weight loss, body pain, night sweats, headaches, dizziness, and fatigue may develop. These are not just confined to the area of the affected nodes but are indicative of the body’s overall response to cancer.
  • Change in Consistency: Affected lymph nodes may feel hard or rubbery upon examination. This change in consistency can be a sign that the normal architecture of the lymph node has been disrupted by the presence of cancer cells.
  • Pain or Tenderness: While swollen lymph nodes are typically painless, in some cases, they can become painful. This might happen when the enlarged node presses on structures like nerves or when there’s inflammation.
  • Size Persistence: Unlike swollen nodes due to infections, which usually return to normal size, nodes affected by cancer often remain enlarged and do not fluctuate in size.
  • Rate of Growth: The speed at which the nodes enlarge can also be a sign. Rapid enlargement may be more suggestive of cancer, especially if it’s unaccompanied by other symptoms like fever.

Some patients will experience all of these symptoms, and some will experience none. Therefore, a follow-up question may be: “Is cancer of the lymph nodes terminal if there are more symptoms?”

The fact is symptoms vary based on where the cancer has spread to and how aggressive it is. It’s important to identify cancerous growths immediately to prevent their spread to other areas. When isolated to a certain region, the chances of it being terminal are less likely.

Diagnosing Cancer of the Lymph Nodes

In addition to a lymph node biopsy, the TNM (tumor, number, metastasis) system is commonly used to issue a diagnosis and determine which type of treatment is best. The ‘T’ refers to the size of the tumor or cancerous growth. The ‘N’ refers to the number of lymph nodes that contain cancerous cells. And, the ‘M’ is for metastasis, which refers to cancer that’s spread to areas far from the originating tumor.5

This categorization is used in addition to other diagnostic tests and tools to determine the cancer stage such as:

  • Imaging tests – X-rays, CT scans, MRIs, and other types of imaging tests can provide a clearer picture and more information about where the cancer is located and how much is present.
  • Endoscopy exams – An endoscope is a thin, lighted tube with a video camera attached that looks around the inside of the body for cancerous areas.

In general, cancers assigned as Stage I are less advanced and have a better prognosis and response to treatment. Whereas, a higher stage indicates that the cancer has spread further and requires a more intense or multiple types of treatment. Other factors that affect treatment are:

  • Location of the tumor – Even if cancer spreads to the lymph nodes, determining where the tumor originates can affect the prognosis and treatment.
  • Blood levels – The blood levels of tumor markers can also affect which stage is assigned during a cancer diagnosis. For example, the level of prostate-specific antigen in the blood is a measure to account for stage assignment for prostate cancer.
  • Person’s age – How old a patient is at the time of diagnosis can also affect the outlook and the kind of treatment prescribed.

When is Cancer of The Lymph Nodes Considered Terminal? 

When it comes to understanding when cancer of the lymph nodes is terminal, it’s important to consider the overall spread and impact of the disease. Cancer is generally termed as terminal when it has become widespread or metastatic and is no longer responding to treatment.

In the context of lymph node involvement, this means the cancer has not only affected the lymph nodes but has also spread to other parts of the body and is impacting vital functions.

Recognizing these signs is key in assessing the progression of cancer. Timely and effective treatment can significantly impact the prognosis, even in cases where cancer has spread to the lymph nodes.

Minimally Invasive, Alternative Cancer Therapies

Since not all cancer diagnoses are the same, neither are the types of treatment administered. Creating a customized course of care is based on the stage, type, and reaction to cancer treatment a person may have. For example, a person experiencing stage 1 cancer in the lymph nodes may not require as aggressive or as frequent of treatment as someone who has been diagnosed with a later stage.

Fortunately, there are multiple alternative therapies for cancer of the lymph nodes as well as natural treatments for non-Hodgkin lymphoma that have proven effective in helping treat different types of cancer and give people options for their care. A few of these include:


This type of alternative cancer treatment uses your body’s immune cells to target cancerous cells. T cells naturally destroy pathogens and cancer cells. T cells have activity-regulating checkpoints that turn off their offensive potential upon contact with healthy cells. Cancer cells take advantage of this and continue to grow and spread. Immunotherapy uses modified immune cells that can function even upon encountering tumor cells, prevent deactivation, and ultimately eliminate their advancement.

With immunotherapy, sample T cells are obtained and returned to the system intravenously, topically with creams, or orally with pills or tablets. This care method is less invasive and comes with fewer side effects than conventional cancer treatment.

Dendritic Cell Therapy

Dendritic cell-targeted therapy is a specialized form of immunotherapy that has become increasingly administered since its approval in 2010. Research has shown evidence of its therapeutic and protective antitumor immunities, particularly for cancer patients with non-Hodgkin’s lymphoma, melanoma, and glioma.

This treatment works by isolating dendritic cells, which are the most potent type of antigen-presenting cells, with tumor antigen-loaded mature dendritic cells and administering them through a vaccine.

Sonodynamic Therapy

Sonodynamic therapy combines low-intensity ultrasound with unique chemical agents (sonosensitizers). This method is used to generate reactive oxygen species, which can prevent tumor growth and kill off cancerous cells.

This process may be repeated for several days or weeks, depending on your specific treatment plan. It is used as an alternative cancer treatment or is sometimes used to increase the effectiveness of traditional types of care, such as chemotherapy.

Enzyme Therapy

This type of cancer therapy causes natural systemic enzymes to neutralize cancer cells and shrink tumors while promoting immune function. The PEG-KYNAse enzyme specifically has been shown to support the immune system’s ability to stop tumor growth and kill cancer cells. Simultaneously, this type of systemic enzyme therapy can also enhance nutritional health in patients experiencing weight loss and malnutrition as a side effect of their cancer diagnosis.

A few of the many alternative cancer therapies are available to treat tumors and cancerous cells in their various stages. Not all cancers of the lymph nodes are terminal cancer. Many can be treated and eliminated with time.

Furthermore, a cancer diagnosis doesn’t mean one set path for treatment. With the increased availability and research supporting holistic therapies, it gives patients an alternative to traditional treatments, such as chemotherapy and radiation therapy. The type and frequency will vary from person to person. An effective plan is based on several factors, customized to the patient, and monitored for progress. There are different avenues to choose from to ensure the best possible care for you.

Living with Lymph Node Cancer

Living with lymph node cancer presents unique challenges, but with the right approach and support, individuals can manage their condition effectively. It’s about adapting to new routines, embracing supportive therapies, and maintaining a quality of life. Here are some key aspects to consider:

Understanding Your Diagnosis

Knowledge is power. Understanding the specifics of your lymph node cancer, including its stage and the affected areas, is crucial. This helps in making informed decisions about treatment options and lifestyle changes.

Lifestyle Adjustments

Small changes can make a significant difference. Maintaining a balanced diet, incorporating gentle exercise routines, and getting adequate rest are fundamental. It’s also important to minimize stress, as stress can affect your immune system and overall health.

Emotional and Mental Well-being

Living with cancer can be emotionally taxing. Seeking emotional support through counseling, support groups, or therapy can be incredibly beneficial. Immunity Therapy Center understands this and offers resources and support to help navigate these emotional challenges.

Regular Monitoring

Regular check-ups and monitoring are essential. They help in tracking the progress of your treatment, making adjustments as necessary, and catching any changes early.

Support System

Building a strong support system of family, friends, and healthcare providers is crucial. They can provide emotional support, assist with daily tasks, and help navigate the healthcare system.

Living with lymph node cancer requires a multi-faceted approach. It’s about combining the best of traditional and alternative treatments, making lifestyle changes, and having a robust support system. At Immunity Therapy Center, we are committed to providing our patients with personalized cancer care and support, helping them live fuller, healthier lives even while battling cancer.

Additional Questions? Reach out to Immunity Therapy Center today to learn more about alternative cancer treatment options.


Written By: Dr. David Alvarez

Dr. David Alvarez is a Board Certified Medical Doctor from Universidad Xochicalco and Certified by the American Heart Association (Advanced Cardiovascular Life Support).

Dr. Alvarez has been collaborating with Dr. Bautista as an Assistant Medical Director at the Immunity Therapy Center for over 6 years. He provides daily on site patient care and participates on the medical board on research and development of patient treatment plans and programs. Dr. Alvarez is a knowledgeable and compassionate Doctor committed to helping patients get to where they want to be health wise through a more holistic and comprehensive approach.



  1. What Happens When Cancer Spreads to the Lymph Nodes?
  2. American Cancer Society. Lymphoma Cancer.
  3. American Cancer Society. What Is hodgkin’s Lymphoma?’s-lymphoma/about/what-is-hodgkin’s-disease.html
  4. American Cancer Society. What Is Non-hodgkin’s Lymphoma?’s-lymphoma/about/what-is-non-hodgkin’s-lymphoma.html
  5. American Cancer Society. Cancer Staging.


October 29, 2023

Dr. Carlos Bautista is a Board Certified Medical Doctor. He received his Medical Degree from Universidad Autónoma de Baja California and has more than 20 years of experience working with Alternative Medicine to treat cancer, autoimmune diseases, chronic degenerative diseases, and infectious diseases. He opened Immunity Therapy Center in 2007 with the goal of providing the highest quality medical care for more than 5,000 patients.

At Immunity Therapy Center, our goal is to provide objective, updated, and research-based information on all health-related topics. This article is based on scientific research and/or other scientific articles. All information has been fact-checked and reviewed by Dr. Carlos Bautista, a Board Certified Medical Doctor at Immunity Therapy Center. All information published on the site must undergo an extensive review process to ensure accuracy. This article contains trusted sources with all references hyperlinked for the reader's visibility.